1 |
drugs |
antiviral |
in vitro |
screening |
coronavirus |
peptides |
delivery |
influenza |
inhibitors |
ebola |
hepatitis |
agonists |
JEV |
UPS |
mabs |
2 |
clinical |
viral |
vitro |
discovery |
sars-cov-2 |
antimicrobial |
rnai |
M2 |
norovirus |
EBOV |
DNA |
diabetes |
RSV |
ubiquitin |
monoclonal |
3 |
drug |
viruses |
infection |
drug |
COVID-19 |
natural |
sirna |
IAV |
protease |
GS-5734 |
simplex |
derivatives |
diarrhea |
IFN |
antibodies |
4 |
diseases |
virus |
vivo |
virtual |
sars-cov |
peptide |
interference |
H5N1 |
molecule |
ebola virus |
HCV |
ferroquine |
encephalitis |
oncolytic |
HCV |
5 |
development |
host |
effect |
compounds |
SARS |
amps |
antisense |
H1N1 |
enzyme |
EVD |
HRV |
antimalarials |
assay |
proteasome |
CQ |
6 |
therapeutic |
replication |
in vivo |
docking |
syndrome |
natural products |
gene |
pandemic |
3clpro |
fatality |
cytomegalovirus |
malaria |
VEEV |
dubs |
monoclonal antibodies |
7 |
review |
antiviral drugs |
activity |
lead |
mers-cov |
products |
sirnas |
neuraminidase |
small molecule |
niv |
HCMV |
effects |
SCV |
signaling |
HCQ |
8 |
studies |
development |
cells |
virtual screening |
respiratory |
bacteria |
nucleic |
avian |
inhibitor |
africa |
infections |
antimalarial |
aureus |
CEP |
mab |
9 |
current |
viral infections |
chloroquine |
silico |
coronaviruses |
activities |
drug delivery |
oseltamivir |
x-ray |
favipiravir |
herpes |
niclosamide |
rotavirus |
oncolytic viruses |
antibody |
10 |
trials |
infections |
results |
in silico |
middle |
antibiotics |
RNA |
seasonal |
proteases |
fever |
HBV |
HCT |
fda-approved |
cancer |
p7 |
11 |
recent |
RNA |
model |
drug candidates |
east |
bacterial |
oligonucleotides |
neuraminidase inhibitors |
gastroenteritis |
conducted |
HEV |
lymphatic |
EV71 |
stroke |
escape |
12 |
therapies |
antivirals |
treatment |
target |
2019 |
marine |
rna interference |
influenza viruses |
rdrp |
amodiaquine |
nucleoside |
anthelmintic |
S. |
DUB |
htas |
13 |
patients |
human |
inhibitory |
chemical |
acute respiratory syndrome |
antibiotic |
systems |
anti-influenza |
active site |
case fatality |
hiv infections |
NM |
CPV |
serms |
cocktail |
14 |
animal |
antiviral agents |
showed |
design |
remdesivir |
sources |
mirnas |
influenza a virus |
scaffolds |
nipah |
NS5B |
p-pd |
SMA |
1996 |
antibody-based |
15 |
clinical trials |
proteins |
study |
computational |
MERS |
microbial |
targeted |
amantadine |
protease inhibitors |
BCX4430 |
syncytial |
antimalarial drugs |
cryptosporidiosis |
tumor |
mutants |
16 |
efficacy |
entry |
inhibited |
drug discovery |
china |
resistance |
antisense oligonucleotides |
channel |
macrocyclic |
nvis |
common |
lipid |
growth |
pharmacological |
epitopes |
17 |
treatment |
drugs |
antiviral |
protein |
2019-ncov |
properties |
ARDS |
H3N2 |
noroviruses |
arenavirus |
analogues |
effects of |
cryptosporidium |
antitumor |
genotype |
18 |
approaches |
targets |
concentrations |
identification |
acute |
organisms |
vectors |
diphyllin |
structure-based |
countermeasures |
ii |
metabolism |
breast |
anti-cancer |
SL |
19 |
disease |
agents |
demonstrated |
pharmacophore |
severe |
fungi |
material |
pandemics |
small |
propose |
herpes simplex virus |
side |
s. aureus |
ifn-ω |
positions |
20 |
approved |
ZIKV |
mouse |
targets |
emetine |
activity |
interfering |
influenza virus |
substrate |
outbreaks |
cold |
dual |
children |
parkinson |
microbial diseases |
21 |
treat |
viral diseases |
inhibition |
HTS |
cov |
plants |
users |
influenza virus infection |
site |
BSL-4 |
EV-D68 |
AD |
library |
enzymes |
cyclophilin |
22 |
promising |
resistance |
antiviral activity |
high-throughput |
middle east respiratory syndrome coronavirus |
extracts |
SUPPLEMENTARY |
hemagglutinin |
3CL |
DEF201 |
i.e. |
immunomodulators |
japanese |
immunity |
genotypes |
23 |
provide |
HIV |
effective |
molecular |
pandemic |
antimicrobial peptides |
authorized |
SP-D |
structure |
SFTSV |
half |
bcl-2i |
SMN |
cellular |
DMD |
24 |
models |
immunodeficiency |
virus |
process |
spread |
plant |
supplementary |
HA |
acute gastroenteritis |
tpcs |
chronic |
tetracyclines |
ouabain |
bortezomib |
unborn |
25 |
potential |
cycle |
agent |
drug design |
drugs |
venoms |
version |
influenza pandemic |
picornavirus |
containment |
hepatitis b |
plasmodium |
bactericidal |
cancer therapy |
anti-adhesion |
26 |
treating |
targeting |
identified |
throughput |
ritonavir |
scorpion |
online |
export |
anti-norovirus |
boosted |
HSV |
NAFLD |
SMD1168H-TOPOI |
modulators |
daas |
27 |
action |
broad-spectrum |
nitazoxanide |
affinity |
lopinavir |
environment |
facilitate |
2009 |
indole |
biosafety |
dna viruses |
melanoma |
poliovirus |
kinases |
GT3 |
28 |
mortality |
viral replication |
recombinant |
ligand |
mpro |
antifungal |
systemic |
influenza virus infections |
design |
SFTS |
© |
glucose |
closantel |
receptor |
GT4 |
29 |
treatments |
vaccines |
ribavirin |
drug discovery process |
acute respiratory syndrome coronavirus |
antimicrobial activity |
therapeutic |
AP3 |
small molecule inhibitors |
proofreading |
iii |
macrophages |
parasite |
ubiquitin pathway |
interferon-free |
30 |
research |
life |
concentration |
libraries |
proteinase |
antibacterial |
therapy |
v-atpase |
norovirus infection |
west africa |
ENF |
DPP-4 |
enterovirus 71 |
type i ifn |
immunoglobulin |
31 |
including |
infection |
cell |
structure |
hcov |
candida |
online version |
drug-resistant |
structural |
haemorrhagic |
GA |
side effects |
camptothecin |
innate immunity |
immune |
32 |
advances |
important |
CHIKV |
candidates |
spike |
lectins |
barriers |
T20 |
replicon |
ebola virus disease |
ARB |
swine |
ML-HSA |
S6 |
total |
33 |
agents |
factors |
FCV |
active |
middle east respiratory syndrome |
antimicrobial drugs |
cpps |
drug-resistant viruses |
WNV |
post-exposure |
ribavirin |
MS |
multiplication |
proteasome inhibitors |
transduced |
34 |
overview |
polymerase |
μm |
based |
main |
due |
INFORMATION |
shedding |
SERT |
RVFV |
chronic hepatitis b |
enterocyte |
equine |
activators |
pre-exposure |
35 |
made |
viral proteins |
reduction |
compound |
mers-cov. |
found |
vascular |
mtb |
crystal |
arenaviruses |
CMV |
rheumatoid |
anti-ev71 |
ifn‐β |
government |
36 |
numerous |
human immunodeficiency virus |
feline |
hits |
homology |
natural product |
liposomes |
DP2392-E10 |
crystallography |
case |
periodicals |
anti-trypanosomal |
TI |
OV |
ebovs |
37 |
effective |
target |
test |
identified |
wuhan |
antimicrobial activities |
organs |
viruses |
JNK |
chlorpromazine |
wiley |
GALT |
platelet |
FAN |
IND |
38 |
evidence |
treatment |
antiviral effect |
3D |
rapidly |
SM21 |
directed |
hiv-infected |
catalytic |
cifn-α |
formally |
steatosis |
sitafloxacin |
TET |
interferon-based |
39 |
success |
genetic |
load |
approach |
protease |
eval418 |
lung |
epithelial |
norovirus 3cl protease |
MHV |
res |
lupus |
drug library |
dopamine |
u.s. food and drug administration |
40 |
— |
zika |
effects |
programs |
anti-coronavirus |
gossypol |
targeting |
influenza infection |
ncrna |
nipah virus |
immediate-early |
apoptosis |
projects |
tumors |
cyclophilin inhibitors |
41 |
past |
dengue |
griffithsin |
learning |
sars-cov infection |
present |
target |
hiv-1 strains |
focused |
curve |
med |
rheumatoid arthritis |
EV-71 |
parkinson’s disease |
invariant |
42 |
effects |
genome |
prevented |
secondary |
mers-cov infection |
infectious |
expression |
bafilomycin |
genus |
ebolavirus |
conjugate |
tβ4 |
retrocyclins |
RAS |
HDL |
43 |
safety |
inhibitors |
therapeutic |
experimentally |
CVL218 |
agents |
vehicles |
pandemic influenza |
βglu |
ntds |
VZV |
activating |
breast cancer |
kinase |
biothreat |
44 |
summarize |
antiviral therapeutics |
vero |
identify |
sars-cov. |
polyether |
nucleic acids |
iavs |
viral protease |
TPC2 |
colds |
aips |
71 |
anticancer |
federal |
45 |
molecules |
play |
replication |
billion |
spreading |
antiviral properties |
therapeutic molecules |
slices |
dipeptidyl |
LASV |
recipients |
tα1 |
reporter |
hematological |
couples |
46 |
repurposed |
enveloped |
disease |
optimized |
hiv-1 protease inhibitors |
pomegranate |
ill |
PAM |
SP600125 |
dosed |
no. |
GLP-1 |
hit |
CXCR4 |
REGN3051 |
47 |
approval |
viral life cycle |
ifn-α |
chemical libraries |
2020 |
scorpions |
deliver |
TCAD |
probiotics |
lethal |
hepatitis c virus |
body weight |
motor |
endolysosomal |
adhesins |
48 |
clinical studies |
potential |
FIP |
NMR |
interactome |
efflux |
designed |
verdinexor |
sars-cov-2 3clpro |
rates |
GS‐6620 |
poly |
screening |
ischemic |
REGN3048 |
49 |
context |
antiviral compounds |
cytotoxicity |
active compounds |
ivermectin |
ctry2459 |
messenger |
classes |
norovirus 3c-like protease |
severe |
vi |
hopping |
strain |
ovs |
AO |
50 |
benefits |
host factors |
symptoms |
protein targets |
signatures |
natural sources |
ribozymes |
strains |
norovirus infections |
outbreak |
cidofovir |
absorption |
high-throughput |
radiation |
restore |