Topic 05 -- Abstracts with Biological Entities (English) - 75 Topics / Sub-Topic Model 13 - 15 Topics

cite ad title authors publish year publish time dataset abstract mentions covid pmcid pubmed id doi cord uid topic weight Similarity scispacy Similarity specter
1 Raghuwanshi_2012 Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein Raghuwanshi, Dharmendra; Mishra, Vivek; Das, Dipankar; Kaur, Kamaljit; Suresh, Mavanur R. 2012 2012-03-20 PMC N PMC3322645 22356166.0 10.1021/mp200553x 0533r1yj 0.615633 Jiang_2006, Montefiori_2007 Garu_2016, Chen_2013, Wang_2008, Sarkar_2013
2 Zacharias_2018 Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections Zacharias, Zeb R.; Ross, Kathleen A.; Hornick, Emma E.; Goodman, Jonathan T.; Narasimhan, Balaji; Waldschmidt, Thomas J.; Legge, Kevin L. 2018 2018-08-28 COMM-USE N PMC6127617 30233573.0 10.3389/fimmu.2018.01953 wlw8cty8 0.590432 Montefiori_2007 Elliott_2017, Gerber_1990, Akahata_2010
3 Hangalapura_2011 Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an Adenovirus based melanoma vaccine Hangalapura, Basav N; Oosterhoff, Dinja; Gupta, Tarun; de Groot, Jan; Wijnands, Pepijn GJTB; van Beusechem, Victor W.; den Haan, Joke; Tüting, Thomas; van den Eertwegh, Alfons JM; Curiel, David T; Scheper, Rik J; de Gruijl, Tanja D 2011 2011-03-09 PMC N PMC3058128 21272606.0 10.1016/j.vaccine.2011.01.022 onq5f40g 0.586644 Montefiori_2007 Hutzler_2017
4 Czerkinsky_2006 Mucosal immunity and tolerance: relevance to vaccine development Czerkinsky, Cecil; Anjueie, Fabienne; McGhee, Jerry R.; Geoige‐Chundy, Annie; Holmgren, Jon; Kieny, Marie‐Paule; Fujiyashi, Kohlaro; Mestecky, Jiri F.; Pierrefite‐Carle, Valérie; Rusk, Carok; Sun, Jia‐Bin 2006 2006-04-28 PMC N PMC7165636 10566152.0 10.1111/j.1600-065x.1999.tb01339.x 695yvdcr 0.573979 Montefiori_2007
5 Dzharullaeva_2018 Stimulation of Dectin-1 and Dectin-2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa Dzharullaeva, Alina S.; Tukhvatulin, Amir I.; Erokhova, Alina S.; Bandelyuk, Alina S.; Polyakov, Nikita B.; Solovyev, Andrey I.; Nikitenko, Natalia A.; Shcheblyakov, Dmitry V.; Naroditsky, Boris S.; Logunov, Denis Y.; Gintsburg, Alexander L. 2018 2018-03-14 COMM-USE N PMC5872666 29725603.0 10.1155/2018/3835720 9zq9f9gu 0.527080 Li_W_2013, Rowe_2019, Wang_2012
6 Rhee_2020 Chapter 19 Current and New Approaches for Mucosal Vaccine Delivery Rhee, Joon Haeng 2020 2020-12-31 PMC N PMC7149853 10.1016/b978-0-12-811924-2.00019-5 7rmzaau4 0.526042 Montefiori_2007, Mooney_2013, Tripp_2014, Lee_S_2015, Wiersma_2015 Kraan_2014, Wilson_2020, Corthésy_2018, Bivas-Benita_2005
7 Chen_2013 Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes Chen, Liulin; Zhu, Junming; Li, Yuhong; Lu, Jie; Gao, Li; Xu, Huibi; Fan, Mingwen; Yang, Xiangliang 2013 2013-08-20 COMM-USE N PMC3748075 23977186.0 10.1371/journal.pone.0071953 3t97ubzc 0.519965 Montefiori_2007 Liu_Z_2013, Raghuwanshi_2012
8 Corthésy_2018 Lipid-Based Particles: Versatile Delivery Systems for Mucosal Vaccination against Infection Corthésy, Blaise; Bioley, Gilles 2018 2018-03-07 COMM-USE N PMC5845866 29563912.0 10.3389/fimmu.2018.00431 bdi8v79t 0.513585 Montefiori_2007 Wilson_2020, Bivas-Benita_2005, Liu_H_2013, Cordeiro_2015
9 Liu_H_2013 Evaluation of Mucosal and Systemic Immune Responses Elicited by GPI-0100- Adjuvanted Influenza Vaccine Delivered by Different Immunization Strategies Liu, Heng; Patil, Harshad P.; de Vries-Idema, Jacqueline; Wilschut, Jan; Huckriede, Anke 2013 2013-07-31 COMM-USE N PMC3729563 23936066.0 10.1371/journal.pone.0069649 or0czzdp 0.505735 Montefiori_2007, Thirugnanam_2007, Bolton_2012, Barefoot_2009 Rowe_2019, Hu_M_2007, Lin_K_2012, dos_SANTOS_2019
10 Zaman_2012 Strategies for intranasal delivery of vaccines Zaman, Mehfuz; Chandrudu, Saranya; Toth, Istvan 2012 2012-07-12 COMM-USE N PMC3539070 23316448.0 10.1007/s13346-012-0085-z kb2wrxio 0.505510 Montefiori_2007, Curtiss_2015 Kraan_2014, Bivas-Benita_2005, Corthésy_2018
11 Morein_1996 Novel adjuvants and vaccine delivery systems Morein, Bror; Villacrés-Eriksson, María; Sjölander, Anders; Lövgren Bengtsson, Karin 1996 1996-11-30 PMC N 8988882.0 10.1016/s0165-2427(96)05697-8 5qt63e48 0.498926 Montefiori_2007 Liu_H_2013, Rowe_2019, Corthésy_2018, Zhang_2016
12 Chen_2010 Vaccination Strategies to Promote Mucosal Antibody Responses Chen, Kang; Cerutti, Andrea 2010 2010-10-29 None N PMC3045856 21029959.0 10.1016/j.immuni.2010.09.013 jxv1ntp8 0.479230 Montefiori_2007 Bivas-Benita_2005, Wilson_2020, Liu_H_2013, Corthésy_2018
13 Saif_1996 Mucosal immunity: an overview and studies of enteric and respiratory coronavirus infections in a swine model of enteric disease Saif, Linda J. 1996 1996-11-30 PMC N PMC7119851 8988861.0 10.1016/s0165-2427(96)05702-9 w1dhk6kc 0.478663 Montefiori_2007 Lin_K_2012, Guo_X_2008, Gerber_1990
14 Rowe_2019 A Novel Supplementation Approach to Enhance Host Response to Sublingual Vaccination Rowe, John C.; Attia, Zayed; Kim, Eunsoo; Cormet-Boyaka, Estelle; Boyaka, Prosper N. 2019 2019-01-24 COMM-USE N PMC6346055 30679470.0 10.1038/s41598-018-36370-8 dmpoy0b1 0.478500 Montefiori_2007 Gerber_1990, Liu_H_2013, Zhang_2016
15 Si_Y_2018 Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses Si, Youhui; Wen, Yi; Kelly, Sean H.; Chong, Anita S.; Collier, Joel H. 2018 2018-07-28 PMC N 29673645.0 10.1016/j.jconrel.2018.04.031 l9vu6mo1 0.478443 Takagi_2013, Rowe_2019, Liu_H_2013
16 Li_J_2018 Intranasal immunization with Mycobacterium tuberculosis Rv3615c induces sustained adaptive CD4(+) T‐cell and antibody responses in the respiratory tract Li, Jiangping; Zhao, Jun; Shen, Juan; Wu, Changyou; Liu, Jie 2018 2018-10-24 COMM-USE N PMC6307849 30353641.0 10.1111/jcmm.13965 i76dxar6 0.471768 Montefiori_2007, Wang_2011, Sereinig_2006 dos_SANTOS_2019
17 Xia_Y_2015 Chitosan-based mucosal adjuvants: Sunrise on the ocean Xia, Yufei; Fan, Qingze; Hao, Dongxia; Wu, Jie; Ma, Guanghui; Su, Zhiguo 2015 2015-11-04 PMC N 26271831.0 10.1016/j.vaccine.2015.07.101 4qfe8kok 0.467376 Montefiori_2007, Lee_S_2015 Cordeiro_2015, Kraan_2014, Corthésy_2018, Sarkar_2013
18 Nagatomo_2015 Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus Nagatomo, Daiki; Taniai, Madoka; Ariyasu, Harumi; Taniguchi, Mutsuko; Aga, Miho; Ariyasu, Toshio; Ohta, Tsunetaka; Fukuda, Shigeharu 2015 2015-09-01 COMM-USE N PMC4569761 26421290.0 10.1155/2015/471468 8fxlo3lr 0.457995 Montefiori_2007, Singh_2016 Lee_T_2017, Sarkar_2013, Li_W_2013
19 Girard_2008 Mucosal immunity and HIV/AIDS vaccines Report of an International Workshop, 28–30 October 2007 Girard, Marc P.; Bansal, Geetha P.; Pedroza-Martins, Livia; Dodet, Betty; Mehra, Vijay; Schito, Marco; Mathieson, Bonnie; Delfraissy, Jean-François; Bradac, James 2008 2008-07-29 PMC N PMC7131112 18513838.0 10.1016/j.vaccine.2008.04.051 ku6n3851 0.457612 Montefiori_2007, Mooney_2013 Liu_H_2013, Gerber_1990, Bivas-Benita_2005, Zolla-Pazner_2004
20 Guo_X_2008 Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system Guo, Xueshui; Rosa, Artur J.M.; Chen, Ding-Geng; Wang, Xiuqing 2008 2008-02-15 None N PMC7112697 17983666.0 10.1016/j.vetimm.2007.09.016 m4nnncsf 0.455193 Montefiori_2007 Lin_K_2012, dos_SANTOS_2019
21 Wilson_2020 Chapter 48 Mucosal Vaccine Development for Veterinary and Aquatic Diseases Wilson, Heather L.; Gerdts, Volker; Babiuk, Lorne A. 2020 2020-12-31 PMC N PMC7149622 10.1016/b978-0-12-811924-2.00048-1 r5va3y1n 0.455151 Montefiori_2007 Bivas-Benita_2005, Liu_H_2013, Lin_K_2012, Corthésy_2018
22 Kraan_2014 Buccal and sublingual vaccine delivery Kraan, Heleen; Vrieling, Hilde; Czerkinsky, Cecil; Jiskoot, Wim; Kersten, Gideon; Amorij, Jean-Pierre 2014 2014-09-28 PMC N PMC7114675 24911355.0 10.1016/j.jconrel.2014.05.060 vq72zw0n 0.423096 Montefiori_2007, Lee_S_2015, Curtiss_2015 Bivas-Benita_2005, Wilson_2020, Rowe_2019, Hansen_2012
23 Langenmayer_2018 Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S Langenmayer, Martin C.; Lülf-Averhoff, Anna-Theresa; Adam-Neumair, Silvia; Fux, Robert; Sutter, Gerd; Volz, Asisa 2018 2018-07-31 PMC N PMC7128986 29759890.0 10.1016/j.biologicals.2018.05.004 1vp8r4er 0.396881 Gerber_1990, dos_SANTOS_2019, Meseda_2016
24 Huang_2007 Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells Huang, D; Pereboev, A V; Korokhov, N; He, R; Larocque, L; Gravel, C; Jaentschke, B; Tocchi, M; Casley, W L; Lemieux, M; Curiel, D T; Chen, W; Li, X 2007 2007-11-29 PMC N PMC7091597 18046426.0 10.1038/sj.gt.3303085 qzno50i1 0.391899 Wyatt_2008 Takagi_2013
25 Shim_2013 Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity Shim, Byoung-Shik; Choi, Youngjoo; Cheon, In Su; Song, Man Ki 2013 2013-06-30 NONCOMM N PMC3718922 23885221.0 10.4110/in.2013.13.3.81 f6q6q3io 0.387426 Montefiori_2007, Curtiss_2015, Mooney_2013 Kraan_2014, Wilson_2020, Rowe_2019, Bivas-Benita_2005
26 Bivas-Benita_2005 Pulmonary DNA vaccination: Concepts, possibilities and perspectives Bivas-Benita, Maytal; Ottenhoff, Tom H.M.; Junginger, Hans E.; Borchard, Gerrit 2005 2005-09-20 PMC N PMC7114572 16054263.0 10.1016/j.jconrel.2005.05.028 1n0o6w67 0.384802 Montefiori_2007, Lee_S_2015, Tripp_2014 Wilson_2020, Liu_H_2013, Lin_K_2012, Corthésy_2018
27 Wang_2017 Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes Wang, Ting; Yin, Huiquan; Li, Yan; Zhao, Lingxiao; Sun, Xiahui; Cong, Hua 2017 2017-04-03 COMM-USE N PMC5399536 28367800.0 10.1051/parasite/2017013 1ay8y7li 0.383784 Hu_M_2007, Sunden_2010, Zakhartchouk_2005 Gerber_1990, dos_SANTOS_2019
28 Shim_2012 Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain Shim, Byoung-Shik; Stadler, Konrad; Nguyen, Huan Huu; Yun, Cheol-Heui; Kim, Dong Wook; Chang, Jun; Czerkinsky, Cecil; Song, Man Ki 2012 2012-09-21 COMM-USE N PMC3489719 22995185.0 10.1186/1743-422x-9-215 6gj02k04 0.381808 Montefiori_2007, Schwartz_2007, Singh_2016 Hu_M_2007, Liu_R_2005, Escriou_2014
29 Ramvikas_2017 Chapter Fifteen Nasal Vaccine Delivery Ramvikas, M.; Arumugam, M.; Chakrabarti, S.R.; Jaganathan, K.S. 2017 2017-12-31 PMC N PMC7151830 10.1016/b978-0-323-39981-4.00015-4 y0tbvs3t 0.376383 Montefiori_2007, Lee_S_2015, Mooney_2013, Tripp_2014 Kraan_2014, Corthésy_2018, Bivas-Benita_2005, Wilson_2020
30 Shewen_2009 Challenges in mucosal vaccination of cattle Shewen, P.E.; Carrasco-Medina, L.; McBey, B.A.; Hodgins, D.C. 2009 2009-03-15 PMC N PMC7127216 19046777.0 10.1016/j.vetimm.2008.10.297 gevrlcvy 0.376306 Montefiori_2007, Deville_2012, Tripp_2014 Gerber_1990
31 Hansen_2012 Nanoparticles for transcutaneous vaccination Hansen, Steffi; Lehr, Claus‐Michael 2012 2012-02-20 PMC N PMC3815776 21854553.0 10.1111/j.1751-7915.2011.00284.x 0lsobcnl 0.366044 Montefiori_2007, Welsh_2007, Salvador_2011 Ishii_2008, Kraan_2014, Corthésy_2018, Cordeiro_2015
32 Hu_J_2010 Mucosally delivered peptides prime strong immunity in HLA-A2.1 transgenic rabbits Hu, Jiafen; Cladel, Nancy; Balogh, Karla; Christensen, Neil 2010 2010-05-01 PMC N PMC2879011 20332046.0 10.1016/j.vaccine.2010.03.015 tbbl91j1 0.364696 Montefiori_2007, Bolton_2012, Kim_S_2013, Deville_2012 Liu_H_2013, Hao_H_2008
33 Curtiss_2015 Chapter 64 Antigen Delivery System II Development of Live Attenuated Bacterial Vectors Curtiss, Roy 2015 2015-12-31 PMC N PMC7148735 10.1016/b978-0-12-415847-4.00064-1 xa6km2ev 0.363202 Montefiori_2007 Tarahomjoo_2011, Lee_T_2017, Corthésy_2018
34 D’Souza_2015 Chapter 5 Trends in Nonparenteral Delivery of Biologics, Vaccines and Cancer Therapies D’Souza, Martin J.; Gala, Rikhav P.; Ubale, Ruhi V.; D’Souza, Bernadette; Vo, Trinh Phuong; Parenky, Ashwin C.; Mulla, Nihal S.; D’Sa, Sucheta; D’Souza, Marissa; Braz-Gomes, Kim; D’Souza, Nigel; Chiriva-Internati, Maurizio; Zughaier, Susu 2015 2015-12-31 PMC N PMC7150203 10.1016/b978-0-12-416603-5.00005-5 cldrzet3 0.355343 Montefiori_2007, Mooney_2013, Tripp_2014, Lee_S_2015 Kraan_2014, Cordeiro_2015, Criscuolo_2019
35 Liu_H_2010 The route of inoculation determines the tissue tropism of modified vaccinia tiantan expressing the spike glycoprotein of SARS‐CoV in mice, Liu, Huan; Yu, Wenbo; Tang, Xian; Wang, Haibo; Ouyang, Wenjie; Zhou, Jingying; Chen, Zhiwei 2010 2010-03-24 PMC N PMC7166938 20336714.0 10.1002/jmv.21667 vyx4t42i 0.351163 Schwartz_2007
36 Garg_2017 Advances Towards Painless Vaccination and Newer Modes of Vaccine Delivery Garg, Neha; Aggarwal, Anju 2017 2017-06-16 PMC N PMC7090876 28620730.0 10.1007/s12098-017-2377-2 0s81kuwt 0.346640 Mooney_2013 Criscuolo_2019, Kraan_2014, Meseda_2016, Kim_Y_2011
37 Wu_F_2014 A vesicular stomatitis virus-based mucosal vaccine promotes dendritic cell maturation and elicits preferable immune response against coxsackievirus B3 induced viral myocarditis Wu, Fei; Fan, Xingjuan; Yue, Yan; Xiong, Sidong; Dong, Chunsheng 2014 2014-06-30 PMC N PMC7115516 24874923.0 10.1016/j.vaccine.2014.05.052 8jzjrtpe 0.332369 Montefiori_2007, Singh_2016 Sawada_2011, Wang_2015, Kim_S_2012
38 Lee_T_2017 Outer membrane vesicles harboring modified lipid A moiety augment the efficacy of an influenza vaccine exhibiting reduced endotoxicity in a mouse model Lee, Tae-Young; Kim, Chang-Ung; Bae, Eun-Hye; Seo, Sang-Hwan; Jeong, Dae Gwin; Yoon, Sun-Woo; Chang, Kyu-Tae; Kim, Young Sang; Kim, Sang-Hyun; Kim, Doo-Jin 2017 2017-01-23 PMC N PMC7115551 28024958.0 10.1016/j.vaccine.2016.12.025 zw5pr2ug 0.330572 Montefiori_2007, Schwartz_2007 Jee_P_2017, Lin_K_2012, Sarkar_2013
39 Offit_1994 Rotaviruses: Immunological Determinants of Protection Against Infection and Disease Offit, Paul A. 1994 1994-12-31 PMC N PMC7130874 7817873.0 10.1016/s0065-3527(08)60329-2 y7jp49rj 0.327980 Montefiori_2007, Wang_2011 Gerber_1990, Akahata_2010
40 Cervantes-Barragan_2010 Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity Cervantes-Barragan, Luisa; Züst, Roland; Maier, Reinhard; Sierro, Sophie; Janda, Jozef; Levy, Frederic; Speiser, Daniel; Romero, Pedro; Rohrlich, Pierre-Simon; Ludewig, Burkhard; Thiel, Volker 2010 2010-09-14 PMC N PMC2939679 20844609.0 10.1128/mbio.00171-10 ctikde7d 0.321228 Montefiori_2007 Garu_2016, Hutzler_2017
41 Garu_2016 Genetic Immunization With In Vivo Dendritic Cell-targeting Liposomal DNA Vaccine Carrier Induces Long-lasting Antitumor Immune Response Garu, Arup; Moku, Gopikrishna; Gulla, Suresh Kumar; Chaudhuri, Arabinda 2016 2016-02-29 None N PMC4817821 26666450.0 10.1038/mt.2015.215 tkzwzc57 0.320190 Montefiori_2007, Zakhartchouk_2005, Cervantes-Barragan_2010, Singh_2016 Cervantes-Barragan_2010, Hutzler_2017
42 Lin_K_2012 Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria Lin, Kuan-Hsun; Hsu, Ai-Ping; Shien, Jui-Hung; Chang, Tien-Jye; Liao, Jiunn-Wang; Chen, Jeng-Rung; Lin, Chuen-Fu; Hsu, Wei-Li 2012 2012-07-13 PMC N PMC7115360 22531554.0 10.1016/j.vaccine.2012.04.043 ben6r7n3 0.318713 Montefiori_2007, Schwartz_2007 Gerber_1990, Liu_H_2013
43 Tomar_2018 Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge Tomar, Jasmine; Patil, Harshad P.; Bracho, Gustavo; Tonnis, Wouter F.; Frijlink, Henderik W.; Petrovsky, Nikolai; Vanbever, Rita; Huckriede, Anke; Hinrichs, Wouter L.J. 2018 2018-10-28 PMC N PMC7111335 30218687.0 10.1016/j.jconrel.2018.09.006 q5ij90hu 0.316970 Montefiori_2007, Deville_2012, Lv_L_2014 Liu_H_2013, Sawada_2011, Lee_T_2017
44 Roediger_2008 Heterologous Boosting of Recombinant Adenoviral Prime Immunization With a Novel Vesicular Stomatitis Virus–vectored Tuberculosis Vaccine Roediger, Elizabeth K; Kugathasan, Kapilan; Zhang, XiZhong; Lichty, Brian D; Xing, Zhou 2008 2008-06-30 PMC N 18388911.0 10.1038/mt.2008.59 noyagzc6 0.304358 Montefiori_2007, Sereinig_2006, Bolton_2012 Bolton_2012, Liu_H_2013
45 Temchura_2008 Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus Temchura, Vladimir V.; Tenbusch, Matthias; Nchinda, Godwin; Nabi, Ghulam; Tippler, Bettina; Zelenyuk, Maryna; Wildner, Oliver; Überla, Klaus; Kuate, Seraphin 2008 2008-07-04 PMC N PMC7115564 18538453.0 10.1016/j.vaccine.2008.04.069 dc0n2aqd 0.301524 Sarkar_2013, Takagi_2013, Lee_T_2017
46 Subramaniam_2017 Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs Subramaniam, Sakthivel; Cao, Dianjun; Tian, Debin; Cao, Qian M.; Overend, Christopher; Yugo, Danielle M.; Matzinger, Shannon R.; Rogers, Adam J.; Heffron, C. Lynn; Catanzaro, Nicholas; Kenney, Scott P.; Opriessnig, Tanja; Huang, Yao-Wei; Labarque, Geoffrey; Wu, Stephen Q.; Meng, Xiang-Jin 2017 2017-01-02 PMC N PMC7114527 27784629.0 10.1016/j.virusres.2016.10.007 0p93a2o2 0.300096 Lv_L_2014 Wang_2017, Ma_S_2018